Ed Freedman, Ph.D., is the principal investigator of the ABCD study in Rochester and a co-author of the study. The study is funded by the National Institutes of Health. URMC is one of 21-sites across the country collecting data for the ABCD study, the largest long-term study of brain development and child health.
Researchers analyzed the brain scans of more then 9,000 nine and ten-year-olds and found a change in important brain pathways in those whose mothers retrospectively reported consuming caffeine while pregnant. They found clear changes in how the white matter tracks – which form connections between brain regions – were organized in children whose mothers reported they consumed caffeine during pregnancy.
Investigators analyzed brain scans of more than 9,000 nine and ten-year-old participants in the ABCD study. This gives us a place to start future research to try to learn exactly when the change is occurring in the brain.” candidate in the Medical Science Training Program and first author on the paper published in the journal Neuropharmacology. “Previous studies have shown that children perform differently on IQ tests, or they have different psychopathology, but that could also be related to demographics, so it's hard to parse that out until you have something like a biomarker. “What makes this unique is that we have a biological pathway that looks different when you consume caffeine through pregnancy,” said Zachary Christensen, a M.D/Ph.D. “I suppose the outcome of this study will be a recommendation that any caffeine during pregnancy is probably not such a good idea.”Įlevated behavioral issues, attention difficulties, and hyperactivity are all symptoms that researchers observed in these children. “These are sort of small effects and it’s not causing horrendous psychiatric conditions, but it is causing minimal but noticeable behavioral issues that should make us consider long term effects of caffeine intake during pregnancy,” said John Foxe, Ph.D., director of the Del Monte Institute for Neuroscience, and principal investigator of the Adolescent Brain Cognitive Development or ABCD Study at the University of Rochester. Researchers in the Del Monte Institute for Neuroscience at the University of Rochester Medical Center (URMC) analyzed thousands of brain scans of nine and ten-year-olds, and revealed changes in the brain structure in children who were exposed to caffeine in utero. New research finds caffeine consumed during pregnancy can change important brain pathways that could lead to behavioral problems later in life.
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